| Name | State | County | Total Population | |
|---|---|---|---|---|
| 1. | City of New York | NY | New York | 8,688,336 |
| 2. | City of Los Angeles | CA | Los Angeles | 3,814,386 |
| 3. | City of Chicago | IL | Cook | 2,635,574 |
| 4. | City of Houston | TX | Harris | 2,362,990 |
| 5. | City of Phoenix | AZ | Maricopa | 1,680,720 |
| 6. | City of Philadelphia | PA | Philadelphia | 1,590,580 |
| 7. | City of San Antonio | TX | Bexar | 1,450,229 |
| 8. | City of San Diego | CA | San Diego | 1,384,269 |
| 9. | City of Dallas | TX | Dallas | 1,319,030 |
| 10. | City of Austin | TX | Travis | 1,027,937 |
| 11. | City of Fort Worth | TX | Tarrant | 1,009,303 |
| 12. | City of Jacksonville | FL | Duval | 1,008,868 |
| 13. | City of San Jose | CA | Santa Clara | 1,007,904 |
| 14. | City of Charlotte | NC | Mecklenburg | 944,711 |
| 15. | City of Columbus | OH | Franklin | 933,172 |
| 16. | City of Indianapolis | IN | Marion | 897,368 |
| 17. | City of San Francisco | CA | San Francisco | 866,412 |
| 18. | City of Seattle | WA | King | 773,833 |
| 19. | City of Denver | CO | Denver | 762,261 |
| 20. | Metropolitan Government of Nashville-Davidson | TN | Davidson | 730,276 |